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There were 3 deaths in the metoprolol group and 4 deaths in the coreg group during this 12-month study.

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Although beta-adrenergic receptor blockade is useful in the treatment of anginahypertensionand heart failure there are situations in which sympathetic stimulation is vitalIn patients with severely damaged heartsadequate ventricular function may depend on sympathetic driveIn the presence of AV blockbeta-blockade may prevent the necessary facilitating effect of sympathetic activity on conductionBeta 2adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm and may also interfere with exogenous bronchodilators in such patients.

Ask your pharmacist what to do with any tablets you have left over if your doctor tells you to stop taking themor you find that the expiry date has passed.

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